Abstract:In order to improve the measurement accuracy of pulmonary function and reduce clinical diagnosis errors of respiratory diseases，the precision controlled lung simulator was used for pulmonary lung function measurement calibration. The lung simulation device’s basic structure and principle, the method of calculating gas volume, and work mode were described. The volume errors on flow linearity and all kinds of work mode was studied. The spirometer was calibrated by the lung simulator and its volume relative errors were less than 3.5% for the flow linearity and vital capacity and forced vital capacity, less than 2% for minute ventilation and less than 10.5% for maximum voluntary ventilation. Based on the test data and the analysis, calibrated pulmonary function test values were within the ATS and ERS standards, and this reaches on calibration purposes for the spirometer. Experimental study of lung simulator application provides reference for the extensive use of lung simulation devices. It is the first time in domestic metrology to provide quality control, measurement calibration and traceability for the spirometer device.