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投稿时间：2006-03-24
投稿时间：2006-03-24
中文摘要: 通过研究四羟甲基氯化鏻(THPC)与皮胶原模拟物(甘氨酸、乙二胺和皮粉)反应，间接证明THPC主要与胶原蛋白的氨基结合，可与氨基以n(P)∶n(N)＝1∶2.2形成交联，THPC与羟基和酰胺基均有少量结合，并在pH=8.0时结合量最高。通过31P NMR分析表明THPC与胶原蛋白结合的结构主要是四羟甲基氢氧化鏻(THPOH)或三羟甲基膦(THP)。通过对比明胶被THPC、甲醛和铬盐处理后的等电点变化趋势，分析了THPC鞣制效应，最后可确定THPC与皮胶原的鞣制机理。
Abstract:The reaction mechanism of tetrakis hydroxymethyl phosphonium chloride(THPC) and raw collagen were researched by the simulated materials of collagen including glycin, ethylenediamine and hide powder. It was testified that THPC mainly linked with amino groups of collagen as muiltipoints and the combination mole ratio n(p)∶n(N) was 1∶2.2. The combination capacity of THPC was changed with pH and at pH 8.0 the combination amount was the highest with hydroxy and amido groups, although the reaction was weak. The 31P NMR spectrums indicated that trihydroxymethyl phosphonium hydroxide (THPOH) or trihydroxymethyl phosphine (THP) can combine with collagen. The change trends of glutin isoelectric point after treated with THPC, formaldehyde and chrome salt were researched and the results showed that the tanning property of THPC was good.
文章编号：20070118 中图分类号： 文献标志码：
基金项目:国家自然科学基金资助项目(50573051）；高等学校博士学科专项科研基金资助项目(20050610046)
作者简介:
引用文本：
陈慧,单志华.THPC与皮胶原作用研究[J].工程科学与技术,2007,39(1):88-92.
.The Interaction of THPC with Raw Collagen[J].Advanced Engineering Sciences,2007,39(1):88-92.
引用文本：
陈慧,单志华.THPC与皮胶原作用研究[J].工程科学与技术,2007,39(1):88-92.
.The Interaction of THPC with Raw Collagen[J].Advanced Engineering Sciences,2007,39(1):88-92.